中国荷斯坦牛乳房炎易感性及抗性的全基因组关联分析

doi:10.11843/j.issn.0366-6964.2013.12.007

Abstract

Abstract:

The variation trends of somatic cell count (SCC) in 2 093 Chinese Holsteins in Beijing were analyzed using SAS 9.1. According to the SCC data, all of the cows were divided into two groups, mastitis susceptive cows (case) and resistant cows (control). Based on case-control design, genome-wide association study was further performed. The results showed that six SNPs were significantly relevant to mastitis susceptibility or resistance after Bonferroni adjusting on the chromosome level. Three genes (PRKRIP1, ARHGAP23, TBX21) on BTA19 closely related to inflammation response were discovered near the significant SNP (ARS-BFGL-NGS-78516，P=5.20e-05) within 200 kb. The results provide fundamental data for molecular genetics of mastitis resistance in dairy cattle.

CLC Number:

S823.9⁺1.2

WANG Xiao, XIE Xiao-li, WANG Sheng, QIAN Meng-ying, MA Pei-pei, ZHANG Yuan, SUN Dong-xiao, LIU Jian-feng, DING Xiang-dong, JIANG Li, WANG Ya-chun, ZHANG Yi, ZHANG Sheng-li, ZHANG Qin,YU Ying. Genome-wide Association Study for Mastitis Susceptibility and Resistance in Chinese Holsteins[J]. ACTA VETERINARIA ET ZOOTECHNICA SINICA, 2013, 44(12): 1907-1912.

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Genome-wide Association Study for Mastitis Susceptibility and Resistance in Chinese Holsteins

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